Abstract
Effect of Baliospermum montanum root extract on phagocytosis by human neutrophils
Department of Pharmacognosy, K.L.E.S.'s College of Pharmacy, Belgaum-590 010, India
Correspondence Address:
Kalpana S Patil Department of Pharmacognosy, K.L.E.S.'s College of Pharmacy, Belgaum-590 010 India kalpatil@yahoo.com
Aqueous extract of roots of Baliospermum montanum was evaluated on preliminary basis for immunomodulatory activity by studying neutrophil phagocytic function. The different concentration of (25, 50, 100 mg/ml) of aqueous extract of roots of Baliospermum montanum was subjected to study its effect on different in vitro methods of phagocytosis such as neutrophil locomotion, chemotaxis, immunostimulant activity of phagocytosis of killed Candida albicans and qualitative nitroblue tetrazolium test by using human neutrophils. This preliminary study revealed that Baliospermum montanum extract has stimulated chemotactic, phagocytic and intracellular killing potency of human neutrophils at the different concentration. From the results obtained it can be observed that the aqueous extract of Baliospermum montanum stimulate cell-mediated immune system by increasing neutrophil function.
