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Abstract

Effect of ph on the stability of new antimalarial compound (80/53) n' -3' -acetyl-4', 5' -dihydro-2' -furanyl-n4 -(6- methoxy, 8-quinolinyl)-1,4-pentane diamine.

Author(s): T Monif, P Prakash, AK Dwivedi, D Kulkarni, J PS Sarin
Div. of Pharmaceutics, Central Drug Research Institute, Lucknow-226 001,

Correspondence Address:
T Monif Div. of Pharmaceutics, Central Drug Research Institute, Lucknow-226 001

A study was conducted to determine the effect of pH on antimalarial compound N' -3' -Acetyl-4-5'-dihydro-2' -furanyl-N' -(6-methoxy, 8-quinolinyl)-1, 4-pentane diamine (80/53) [l]. Aqueous solutions of [l] were prepared in buffers of different pH values (2.2 to 8.6) at 25 +/- 2 degree. The order of reaction and degradation rate constant were computed by least square linear regression.

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