Abstract

To observe the effect of propofol in conjunction with sevoflurane in the anesthesia of individuals undergoing laparoscopic cholecystectomy. Randomly divided into a control and observation group, a total of 200 patients undergoing laparoscopic cholecystectomy between June 2022 and June 2023. Propofol was used for maintenance anesthesia in the control group, while a combination of sevoflurane and propofol was administered to the observation group. The observer’s assessment of alertness/sedation score was employed to evaluate the quality of patient recovery at extubation and 15 min post-extubation. Assessment of recovery conditions encompassed the duration required for spontaneous breathing recovery, awakening, and extubation. Furthermore, stress response-related indicators, such as nitric oxide and adrenocorticotropic hormone, were measured. Additionally, any adverse reactions during the treatment period were carefully recorded. Remarkably higher observer’s assessment of alertness/sedation score were observed in the observation group at both extubation and 15 min post-extubation, as opposed to the control group (p<0.05). Prior to the surgery, there were no substantial variations observed in the levels of nitric oxide and adrenocorticotropic hormone between the two groups (p>0.05). Nevertheless, after a 2 d interval from the surgery, both groups experienced a significant escalation in nitric oxide and adrenocorticotropic hormone levels, with the observation group displaying comparatively lower levels than the control group (p<0.05). The administration of propofol in conjunction with sevoflurane demonstrates a positive impact on anesthesia in patients receiving laparoscopic cholecystectomy. This approach not only improves the quality of recovery but also reduces the time required for anesthesia recovery and lowers stress response-related indicators. Most importantly, it ensures safety and provides controllability.