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Effect Of Sodium Lauryl Sulfate On The Release of Rifampicin From Guar Gum Matrix

Author(s): B Sreenivasa Rao, K V Ramana Murthy

The release of rifampicin from a matrix compressed from a physical mixture of rifampicin, guar gum and sodium lauryl sulfate was investigated. When sodium lauryl sulfate was incorporated in the matrix, the release of rifampicin was found to be linearly related to the square root of time, however, the release depended on the concentration of the sodium lauryl sulfate. As the concentration of sodium lauryl sulfate Increased upto 15%, the release progressively slowed to a minimum, which could be due to the formation of a poorly soluble complex. As the concentration increased further, the release increased as the complex was micellarly solubilized.


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