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Effect Of Sulphate Cathartics On Adsorption Of Rifampicin To Activated Charcoal

Author(s): P. U Agbasi, O. E Orisakwe, E Obi, S. I Ofoefule, N. A Ilondu, O. J Afonne

The effect of magnesium sulphate and sodium sulphate on the in vitro adsorption of rifampicin to activated charcoal (AC) was investigated. Solutions of rifampicin alone and rifampicin with 7.5 mg/ml cathartic solution were vortex mixed for 30 s with different quantities of AC, incubated for 30 min at 37o and analyzed for free rifampicin spectrophotometrically at 320 nm. Addition of sodium and magnesium sulphates significantly increased (P<0.05) the adsorption of rifampicin to activated charcoal. In all, the adsorption obeyed quantity-dependent kinetics.


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