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Effectiveness of Iontophoretic Application of Curcumin Extracts among Patients Suffering from Rheumatoid Arthritis

Author(s): M. Miraj*, T. Siddiqui, T. T. Uthup, Ghada M. Shawky, M. Alzhrani, A. Alanazi, M. Alqahtani, A. M. Alduhishy, J. F. Alotaibi, M. M. Aldaihan, F. Ahmad, D. Raghav, R. A. Shaik, F. Kashoo, A. R. Shaik, M. S. Sirajudeen and M. K. Seyam
Department of Physical Therapy and Health Rehabilitation, College of Applied Medical Sciences, Majmaah University, Al Majmaah 11952, Saudi Arabia, 1Department of Hospital Administration, Era University, Lucknow, Uttar Pradesh 226003, India, 2Department of Public Health, College of Health Sciences, Saudi Electronic University, Riyadh 13316, 3Faculty of Applied Medical Sciences, College of Applied Medical Sciences, AlMaarefa University, Dariyah, Riyadh 13713, 4Physical Therapy Department, College of Applied Medical Sciences, Imam Abdulrahman Bin Faisal University, Dammam 34212, 5King Fahd Military Medical Complex, Dhahran 31932, 6Department of Rehabilitation Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 11362, Saudi Arabia, 7Department of Physiotherapy, Santosh College of Physiotherapy, Ghaziabad, Uttar Pradesh 201009, India, 8Department of Family and Community Medicine, College of Medicine, Majmaah University, Al-Majmaah 11952, Saudi Arabia

Correspondence Address:
M. Miraj, Department of Physical Therapy and Health Rehabilitation, College of Applied Medical Sciences, Majmaah University, Al Majmaah 11952, Saudi Arabia, E-mail:

Curcumin has a powerful anti-inflammatory impact, despite its limited absorption when given orally. Earlier research has proved the efficacy of the curcumin extracts in the rat model and therefore the present study is an attempt to evaluate the effects of lyophilized curcumin extracts delivered through iontophoresis among patients suffering from rheumatoid arthritis. Lyophilized curcumin extracts having 29.79 % curcumin as its active ingredient was prepared using standardized method and it was applied to the inflamed hands of the rheumatoid arthritis patients, satisfying the inclusion criteria. Another group of patients were treated with oral curcumin. The prospective study was done among 20 patients at LifeLine Rehab Center who were diagnosed during January 2022 to August 2022. The experimental group use iontophoretically treated curcumin which showed significant improvement as compared to their matched controls. Iontophoretic application of lyophilized curcumin extracts has been found to provide a greater anti-arthritic impact due to improved curcumin penetration and bioavailability. Future studies can be conducted to examine the effects of different curcumin applications in arthritic conditions and examining their action pathways.

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