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Abstract

Effects of Chinese Patent Medicine Shenling Baizhu San on the Immune Functions of Mice Suffering from Chronic Diarrhea with Spleen Deficiency Syndromes

Author(s): H. YU, C. MA1, HONGYING ZHANG2 AND H. GUAN3*
School of Nursing, Jinzhou Medical University, Jinzhou City, Liaoning Province-121000,1Department of Experimental Diagnostics, Jinzhou Medical University, Jinzhou City, Liaoning Province-121000,2Department of Neurology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou City, Liaoning Province-121001,3School of Basic Medicine, Liaoning University of Traditional Chinese Medicine, Liaoning Province-110847, China

Correspondence Address:
H. GUAN, School of Basic Medicine, Liaoning University of Traditional Chinese Medicine, Liaoning Province-110847, China, E-mail: [email protected]


The effects of Chinese patent medicine Shenling Baizhu San on the immune functions of mice with chronic diarrhea with spleen deficiency syndromes were explored. A total of 90 mice were selected as the research objects to analyze the active mechanism and therapeutic effects of Shenling Baizhu San. The rhubarb root and rhizome were applied to construct the mice models with chronic diarrhea with spleen deficiency syndromes. The models were treated by Shenling Baizhu San, and the additional healthy mice were selected as the blank control group. The spleen/thymus weighted index, the immune adhesion function of erythrocytes, the serum amylase content, the serum D-xylose content, and the phagocytosis of macrophages of all the mice were detected and measured. The results have shown that Shenling Baizhu San has a significantly anti-diarrheic function and could increase the body weights of mice who suffered from chronic diarrhea with spleen deficiency syndromes; in addition, Shenling Baizhu San could increase the rosette rate of immune-associated erythrocyte C3b receptors and reduce the rosette rate of erythrocyte immune complex. Thus, it is proved that Shenling Baizhu San could increase the spleen/thymus weighted index, the phagocytosis of macrophages, the serum amylase content, and the drainage ratio of D-xylose of mice suffering from chronic diarrhea with spleen deficiency syndromes. The experiment has indicated that Shenling Baizhu San could increase the anti-inflammatory ability of mice, restore the functions of the gastrointestinal mucosa, maintain the barrier functions of gastrointestinal tracts, and increase the secretion of the duodenum. In addition, it could also enhance immune functions.

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