Abstract

To investigate the effects of dexmedetomidine combined with etomidate on cellular immune function and stress response in patients undergoing radical resection of rectal cancer is the main objective of study. 100 patients with rectal cancer treated by radical resection of rectal cancer were randomly divided into observation group and control group, in which the observation group was given dexmedetomidine combined with etomidate anesthesia, while the control group was given only dexmedetomidine anesthesia. Immune function and oxidative stress response of the two groups were analyzed. There were significant differences in postoperative visual analog scale score, peripheral blood cells and T lymphocyte subsets, oxidative stress, gastrointestinal hormone levels and complication rate between two groups and the differences were statistically significant. The total incidence of complications in observation group was 8.00 %, while that in control group was 24.00 %. In addition, the stress response in observation group was lower than that in control group and the immune function of patients was greatly improved. Dexmedetomidine combined with etomidate could effectively improve cellular immune function and stress response in patients undergoing radical resection of rectal cancer. It has significant clinical effect and is worthy of wide promotion.