Abstract
Effects of Ginsenosides on Microvascular and Immune Microenvironment and Prognosis of Hepatocellular Carcinoma
Department of Infectious Diseases, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, 1Department of Oncology and Hematology, The First People’s Hospital of Longquanyi District, Chengdu, Sichuan 610100, 2Department of Radiology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, 3Department of Medical Oncology, Yancheng No. 1 People’s Hospital, Yancheng, Jiangsu 224006, 4Department of Traditional Chinese Medicine, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, 5Department of Oncology, Affiliated Hospital of Nanjing University of Chinese Medicine, No. 155 Han zhong Road, Nanjing, Jiangsu 210029, China
Correspondence Address:
Peng Shu, Department of Oncology, Affiliated Hospital of Nanjing University of Chinese Medicine, No. 155 Han zhong Road, Nanjing, Jiangsu 210029, China, E-mail: shupengnjucm@163.com
To investigate the effects of ginsenosides on the microvascular and immune microenvironment of hepatocellular carcinoma rats and analyzes the relationship on the prognosis of patients with hepatocellular carcinoma. 60 patients with hepatocellular carcinoma were collected and randomly divided into control and treatment group in our hospital from January 2018 to January 2020 and clinical symptoms improvement and adverse reactions were compared and analyzed. 60 rats were randomly divided into ginsenoside, control and model group. The immune cell infiltration and microvascular density were detected and analyzed. In animal studies, the infiltration of cluster of differentiation 3+, cluster of differentiation 4+, cluster of differentiation 8+ and forkhead box P3+ T lymphocytes increased significantly while the transforming growth factor beta 1 value decreased significantly after treatment with ginsenoside. Clinically, the patients in the treatment group showed significant improvement in their conscious symptoms and higher treatment efficiency while the adverse reactions such as decrease of white blood cell, decrease of hemoglobin, decrease of platelet, nausea and vomiting and low fever than that of in control group. In hepatocellular carcinoma model, ginsenosides induced lymphocyte infiltration and inhibited tumor angiogenesis to exert anti-tumor effects. And ginsenoside has both anti-tumor and quality of life effects and has good efficacy in the treatment of advanced primary hepatocellular carcinoma.
