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Abstract

Effects of Metformin Treatment on Metabolic Indices and Serum Lipid-Derived Sex Hormones in Obese Children with Hyperinsulinemia

Author(s): Minghui Qiu, Y. Zhou and M. Yang*
Department of Pediatrics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, 1Department of Maternal and Child Healthcare, Affiliated Shenzhen Maternity and Child Healthcare Hospital, Southern Medical University, Shenzhen, Guangdong 518028, 2Department of Traumatology and Orthopedics, The People's Hospital of Longhua Shenzhen, Guangdong 518109, 3Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat Sen University, Shenzhen, Guangdong 518107, China

Correspondence Address:
M. Yang, Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat Sen University, Shenzhen, Guangdong 518107, China, E-mail: moyang202306@163.com


The main objective of this study is to investigate the effects of metformin on metabolic indices and serum adiponectin, resistin and leptin levels in obese children with hyperinsulinemia. 90 obese children with hyperinsulinemia admitted to Shenzhen Maternity and Child Healthcare Hospital from March 2021 to March 2023 were divided into two groups, in which the control group was given exercise and diet control, while the research group was given metformin treatment based on the control group. The metabolic indices, serum adiponectin, resistin and leptin levels of the two groups were compared. The effective rate of the study group (95.56 %) was significantly higher than that of the control group (80.00 %). After treatment, the fasting blood glucose, fasting insulin, insulin resistance index (i.e., homeostatic model assessment for insulin resistance) and body mass index in the study group were significantly lower than those in the control group. After treatment, resistin and leptin levels in the study group decreased significantly compared with the control group, and adiponectin increased significantly. The incidence of adverse reactions in the study group was significantly lower than that in the control group. Metformin treatment for obese children with hyperinsulinemia can stabilize their metabolic function, improve serum lipid-derived sex hormones, improve the treatment efficiency and reduce the incidence of adverse reactions, which has high practical value.

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