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Effects of Perindopril and Amlodipine Combined with Shengmai Injection in Elderly Hypertensive with Heart Failure

Author(s): H. Wang, N. Yang, Yingwu Liu and Y. M. Li*
Department of Cardiology, Tianjin Medical University, Jinnan, Tianjin 300051, 1The Third Central Hospital of Tianjin, Hedong, Tianjin 300170, 2TEDA International Cardiovascular Hospital, Binhai, Tianjin 300457, China

Correspondence Address:
Y. M. Li, TEDA International Cardiovascular Hospital, Binhai, Tianjin 300457, China, E-mail:

The main objective of this study is to explore the clinical effect and hemorheology changes of the three drugs combination (misoprostol tablets and Chanfukang granules combined with oxytocin) in the treatment of postpartum hemorrhage in puerpera. 80 postpartum women admitted from November 2014 to January 2022 were divided into study and control groups and were given different drug treatments. After taking the medication, the total efficacy, changes in bleeding scores, height of uterine fundus after 3 d of medication, uterine involution after 10 d of medication, blood rheology changes, milk secretion volume, breast fullness, etc. were observed at different time periods before and after postpartum. After taking the medication, the bleeding score of the study group was better than that of the control group, and the height of uterine fundus was higher than that of the control group. After 10 d of medication, there were statistically significant differences in whole blood low-shear, high-shear viscosity, plasma viscosity, fibrinogen, and red blood cell aggregation index between the study group and the control group (p<0.05). After 3 and 10 d of medication, the lactation scores of the study group were significantly better than those of the control group (p<0.05). The combined application of misoprostol tablets, Changfukang granules and oxytocin can effectively treat postpartum hemorrhage in postpartum women and increases postpartum milk production with high safety.

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