Abstract
Effects of Yougui Pill Combined With Diacerein on Gonitis and Serum Levels of Toll-Like Receptor 4, Matrix Metalloproteinase-3 and Nitric Oxide
Department of Orthopaedics, Zhuji Affiliated Hospital of Shaoxing University, Shaoxing 311800, 1Qingdao Hospital of Traditional Chinese Medicine (Qingdao Hiser Hospital), 2Qingdao Traffic Hospital, Qingdao 266000, 3Jingzhou Traditional Chinese Medicine Hospital, Hubei Province 430000, China
Correspondence Address:
Cheng Zang, Department of Orthopaedics, Zhuji Affiliated Hospital of Shaoxing University, Shaoxing 311800, China, E-mail: Zangcheng1000@163.com
To observe the efficacy of Yougui pill combined with diacerein on gonitis and the effects of serum Tolllike receptor 4, matrix metalloproteinase-3 and nitric oxide. A total of 132 patients with gonitis treated in our hospital from January 2019 to October 2020 were selected and divided according to their treatment regimen. Efficacy: After 8 w of treatment, 28 patients had complete remission in the observation group, accounting for 42.42 %, 25 patients had partial remission, accounting for 37.88 % and 8 patients had remission, accounting for 12.12 %; in the control group, 14 patients had complete remission, accounting for 21.21 %, 21 patients had partial remission, accounting for 31.82 % and 18 patients had remission, accounting for 27.27 %; in the observation group, the overall response rate was higher than that in the control group and it was statistically significant (p<0.05). Serum: After 8 w of treatment, Toll-like receptor 4, matrix metalloproteinase-3 and nitric oxide, erythrocyte sedimentation rate and C-reactive protein in both groups were largely decreased compared with those before treatment (p<0.05) and after 8 w of treatment in the observation group, Toll-like receptor 4, matrix metalloproteinase-3 and nitric oxide, erythrocyte sedimentation and C-reactive protein were lower compared with the control group (p<0.05). Bone and joint function: The pain, daily activities, stiffness and total scores in both groups after 8 w of treatment were greatly decreased compared with those before treatment (p<0.05) and the above scores were lower in the observation group after 8 w of treatment compared with those in the control group (p<0.05). Safety: In the observation group, gastric discomfort occurred in 2 patients, dry mouth in 3 patients and fatigue in 1 patient; in the control group, gastric discomfort occurred in 2 patients and dry mouth in 1 patient; the rate of adverse effects in the observation group was not statistically different from that in the control group (p>0.05). The combination of Yougui pill and diacerein improved the efficacy and decreased the expression of serum related factors without increasing adverse effects in patients with gonitis.
