All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Efficacy of 5 mg Olanzapine in the Prevention and Treatment of Carboplatin-Induced Nausea and Vomiting in the Chinese Population

Author(s): Yun An, Z. H. Li, F. Chen, Caihong Jiang, Juan Zhao, L. Z. Zhao, Ying Jiang, Hui Li, G. Liu, M. Gu, Lenggaowa Da, Gaowa Jin and Q. F. Li*
Department of Medical Oncology, Ordos Central Hospital, Baotou Medical College, Ordos 017000, 1Department of Radiology, School of Public Health and Management, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China

Correspondence Address:
F. Li, Department of Medical Oncology, Ordos Central Hospital, Baotou Medical College, Ordos 017000, China, E-mail: 1729259137@qq.com


To investigate the efficacy and safety of low-dose 5 mg olanzapine triple regimen for prevention of carboplatininduced nausea and vomiting in Chinese population. 56 patients with malignancies were treated with carboplatin (area under the curve≥5) chemotherapy. All patients received a triple antiemetic regimen of 5 mg olanzapine combined with 5-hydroxytryptamine-3 receptor antagonist and dexamethasone. The primary endpoint of the study was total control in the overall phase (0-120 h), acute phase (0-24 h) and delayed phase (25-120 h) in all patients. Secondary endpoints were total protection and complete response in the overall phase, acute phase and delayed phases. The impact of chemotherapy-induced nausea and vomiting on the quality of life was assessed by the functional living index-emesis. Olanzapine related side-effect was also recorded. The primary end points total control in the overall phase, acute phase and delayed phases were 62.50 % (35/56), 87.50 % (49/56) and 64.28 % (36/56) respectively. These end points total protection in the overall phase, acute phase and delayed phases were 82.14 % (46/56), 96.42 % (54/56) and 83.92 % (47/56) respectively. The complete response rate in the overall phase, acute phase and delayed phases were 91.07 % (51/56), 98.21 % (55/56) and 91.07 % (51/56) respectively. There was no effect on life-quality (score≥108) assessed by functional living index-emesis was 62.50 %.The most common olanzapine-related side effects were Grade I-II somnolence and weakness. The 5 mg olanzapine based triplet antiemetic regimen is effective and safe in the prevention carboplatin-induced nausea and vomiting in the Chinese population.

Full-Text | PDF

 
 
Google scholar citation report
Citations : 69022

Indian Journal of Pharmaceutical Sciences received 69022 citations as per google scholar report