All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Efficacy of a Combination of Nimodipine and Edaravone in the Treatment of Acute Cerebral Hemorrhage

Author(s): Suzhen Wang*, Xiaoqin An1, Yuehua Wang, J. Zhang And L. Qi2
Department of Neurosurgery, 1Department of Neurology, Shandong Jiyang Public Hospital, Jinan 251400, 2Department of Neurosurgery, Taian Central Hospital, Taian 271000, China

Correspondence Address:
Department of Neurosurgery, 1Department of Neurology, Shandong Jiyang Public Hospital, Jinan 251400, 2Department of Neurosurgery, Taian Central Hospital, Taian 271000, China, Email: [email protected]

The present study was aimed at evaluating the clinical efficacy of a combination of nimodipine and edaravone in the treatment of acute cerebral hemorrhage. A total of 180 patients diagnosed with acute cerebral hemorrhage and treated at the Shandong Jiyang Public Hospital were enrolled. The patients were divided into the control group and the research group with 90 patients in each group. Patients in the control group were treated with edaravone, while a combination of nimodipine and edaravone was administered to patients in the research group. Total therapeutic efficacy, neurologic impairment score, quality of life score, hematoma and edema volume were compared between both groups. Results obtained demonstrated that the total therapeutic efficacy of the research group was better than that of the control group (p<0.05). Patients’ hematoma and edema volume before and after treatment on comparison indicated that improvement in the research group after drug administration was significantly better than that of the control group (p<0.05). Moreover, there was a greater decrease in the neurologic impairment score of the research group than that of the control group (p<0.05). Application of a combination of nimodipine and edaravone in the treatment of acute cerebral hemorrhage could achieve greater clinical efficacy as well as significantly improve the therapeutic efficiency.

Full-Text | PDF