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Efficacy of Butylphthalide Injection in Conjunction with Citicoline Sodium in Treating Ischemic Stroke

Author(s): Lin Kou, Juan Tan*, Wen Yang, Xiaoyue Liu, Jing Zhou and Rong Liu
Department of Neurology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan Province 637503, China

Correspondence Address:
Juan Tan, Department of Neurology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan Province 637503, China, E-mail:

To observe the clinical efficacy of butylphthalide injection in conjunction with citicoline sodium in treating ischemic stroke. From January 2022 to January 2023, our hospital admitted and randomly assigned 100 patients with acute ischemic stroke into two groups, control group and observation group. Each group consisted of 50 patients. Routine neurological treatment was administered to the control group, involving interventions such as fluid replacement, blood pressure control, lipid regulation, anticoagulation, correction of electrolyte imbalance, and intravenous infusion of butylphthalide injection. In addition to the standard treatment received by the control group, the observation group orally received citicoline sodium tablets. The assessment of therapeutic efficacy took place after duration of 2 w in both groups. Assessment of neurological injury repair was conducted using the national institutes of health stroke scale, while cognitive function recovery was evaluated through the implementation of the Montreal cognitive assessment scale. Utilizing computed tomography scan, cerebral blood volume and cerebral blood flow were quantified. The evaluation of activities of daily living was carried out employing the activities of daily living scale. Moreover, any adverse reactions occurring during the treatment period were duly documented. The occurrence of adverse reactions did not show a significant difference between the two groups, as reflected by a (p>0.05) that indicated no noteworthy disparity. When used in conjunction, butylphthalide injection and citicoline sodium exhibit a synergistic effect in treating ischemic stroke. This integrated treatment approach effectively promotes the repair of neurological injury and enhances cognitive function recovery. Furthermore, it improves cerebral blood flow perfusion and enhances daily life functionality, while maintaining a high level of safety.

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