Abstract

The main objective of this study is to explore the role of dexmedetomidine combined with droperidol in preventing and treating carboprost tromethamine-induced side effects in cesarean section. 240 patients undergoing cesarean section were enrolled in this study and grouped them into the four groups (n=60 for each). Group D treated with dexmedetomidine, group F intervened by droperidol, group DF treated with dexmedetomidine+droperidol and group C given an equal amount of normal saline. The administration dose and rate were the same in all four groups. Pulse oxygen saturation and heart rate were recorded intraoperatively and mean arterial pressure was monitored every 5 min. Monitoring was performed at the time of entering the operating room (T0), before (T1) and 10 min after intrauterine carboprost tromethamine injection (T2), and at the end of surgery (T3). Side effects, blood pressure, heart rate changes, and Ramsay sedation scores were also analyzed. Group DF showed markedly higher Ramsay sedation scores than groups C and F. Along with that group DF showed lower incidence rates of nausea and vomiting, chest tightness, chills, blood pressure drop and tachycardia than group C, with relatively stable hemodynamics. Low-dose dexmedetomidine+droperidol shows promising results in preventing and treating carboprost tromethamine-induced side effects during cesarean section, with superior efficacy, low adverse event rate and high safety, making it safe for clinical use.