Abstract

Skin rupture (open wound) intensifies bacterial colonization in underlying injured tissues. It initiates as a focal infection and might develop into an invasive and systemic infection. Multi-drug resistant bacteria have emerged as a global issue with their rising infections in humans and various animal species. The development of efficient alternative therapies could minimize antibiotic usage by countering antibiotic resistance. Alternative therapies can particularly be beneficial in treating mild infections. Nigella sativa, also known as black cumin or black seeds, is a medicinal herb native to the eastern Mediterranean, Northern Africa, Southwest Asia and the Indian subcontinent. The efficacy of Nigella sativa against Gram-positive and Gram-negative bacteria has been demonstrated in multiple studies. Nigella sativa is known to possess antioxidative, anti-inflammatory, wound healing and antibacterial properties. The antiseptic and antibacterial capability seems to facilitate the speedy recovery of wounds. This review summarizes recent studies related to Nigella sativa wound healing properties.