Abstract

The objective of this study was to evaluate the efficacy and safety of treating herpangina in children using interferon alpha-2b spray combined with Chiqiao Qingre granule. Over a period from January 2021 to December 2022, 240 children with herpangina who were treated at our hospital were randomly divided into four groups; group A received routine treatment, group B was treated with interferon alpha-2b, group C was treated with Chiqiao Qingre granule, and group D was treated with a combination of interferon alpha-2b and Chiqiao Qingre granule. The symptom regression time, serum inflammatory levels, and adverse reactions were observed and compared for 5 d. Interferon alpha-2b, Chiqiao Qingre granule and their combination treatment group all achieved better curative effect, and the combination of interferon alpha-2b and Chiqiao Qingre granule could bring better results, and the difference was not significant in the safety between combined treatment and routine treatment, interferon alpha-2b and Chiqiao Qingre granule alone. The combination of interferon alpha-2b and Chiqiao Qingre granule is an effective and safe therapy for children.