Abstract

This study mainly reports the efficacy of Nei Yi formula with diphereline in patients with ovarian endometriomas after surgery and its influence on ovarian functioning. 115 ovarian endometriomas individuals treated in our hospital were selected from December 2019 to March 2023 and were grouped into a control group (n=55) treated and research group (n=60). Control group was treated with diphereline while the research group was treated with Nei Yi formula on the basis of the control group. The treatment efficacy was evaluated comparing the symptom improvement of dysmenorrhea, breast tenderness, anal swelling and dyspareunia. Further, echocardiographic indices such as antral follicle count, resistance index of ovarian stromal flow, and ovarian cyst diameter were assessed. Additionally, ovarian functioning using serum estradiol, luteinizing hormone and follicle stimulating hormone was compared. Similarly, inflammatory indices such as tumor necrosis factor-alpha and interleukin-10 were also evaluated for comparative analysis. The data revealed a statistically higher overall response rate of treatment in the research group vs. the control group. Besides, the research group exhibited markedly reduced symptom improvement scores, resistance index, ovarian cyst diameter, ovarian function indices and tumor necrosis factor-alpha after treatment, lower than the baseline and the control group; while antral follicle count and interleukin-10 increased significantly after treatment, higher than the baseline and the control group. The above demonstrates the definite efficacy of Nei Yi formula with diphereline in the treatment of endometriomas patients after surgery, which can significantly ameliorate clinical symptoms and echocardiographic indices and facilitate the repair of ovarian function and the suppression of serum inflammation.