Abstract

To investigate the effect of paroxetine combined with comprehensive psychological nursing on coronary heart disease patients with depression is the objective of the study. A total of 160 patients with coronary heart disease complicated with depression were randomly divided into research group (n=80) and control group (n=80). The control group received paroxetine under conventional treatment. The research group was supplemented with comprehensive nursing intervention on the basis of the control group. The total response rate of different medication regimens in the two groups was evaluated. Hamilton anxiety scale and Hamilton depression scale were used to assess the anxiety of the subjects, Pittsburgh sleep quality index was used to assess the sleep quality of the two groups of patients, self-rating anxiety scale and self-rating depression scale were used to evaluate the mental state of the patients. The treatment cycle is 60 d. After treatment, the Hamilton anxiety scale, Hamilton depression scale, Pittsburgh sleep quality index, self-rating anxiety scale and selfrating depression scale scores of the study group were significantly lower than those of the control group and the total effective rate of the study group was significantly higher than that of the control group (p<0.05). Paroxetine has a certain curative effect in the treatment of patients with coronary heart disease complicated with depression, but the effect is better when supplemented with comprehensive psychological nursing, which can more effectively relieve anxiety and improve sleep quality.