Abstract

To look into the efficacy of ropivacaine in conjunction with dexmedetomidine on postoperative pain relief and sleep quality in individuals undergoing laparoscopic cholecystectomy. Allocated into an observation group and a control group, the study enrolled a total of 240 individuals who underwent laparoscopic cholecystectomy from January 2019 to January 2024, with 120 individuals in each group. Local infiltration analgesia with ropivacaine hydrochloride injection was administered in the incision for the control group, while the observation group received a combined local infiltration analgesia with ropivacaine hydrochloride and dexmedetomidine hydrochloride injections. Pain intensity of the incision during rest and activity at 3, 12, 24, and 48 h post-surgery was assessed using the visual analogue scale. Postoperative recovery was evaluated by comparing the first flatus time, first oral intake time, first out-of-bed time, and length of hospital stay between the two groups. The Pittsburgh sleep quality index was employed to evaluate sleep quality at both pre-treatment and post-treatment stages. The occurrence of adverse drug reactions, encompassing incision infection, nausea, vomiting, dizziness, and the cumulative prevalence of adverse reactions, was noted in both groups. The observation group exhibited lower visual analogue scale scores for incisional pain during both rest and activity at 3, 12, 24, and 48 h compared to the control group. The observation group exhibited significantly shorter durations of first flatus time, first oral intake time, first out-of-bed time, and hospital stay compared to the control group. On the 1st d after surgery, the Pittsburgh sleep quality index score was lower in the observation group, indicating an enhancement in sleep quality (p<0.05). The incidence of adverse reactions, including incision infection, nausea, vomiting, dizziness, did not differ significantly between the two groups (p>0.05). To summarize, the results of this research indicate that the concurrent administration of ropivacaine and dexmedetomidine offers advantages in enhancing postoperative pain relief and sleep quality for individuals undergoing laparoscopic cholecystectomy. These findings lend support to the potential utilization of this combination approach in clinical practice.