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Abstract

Efficacy of Shuxuening Injection in Treating Organophosphate Pesticide-Induced Myocarditis

Author(s): Shi Yuanwang, Jia Yingyang, T. S. Li, Jia Rongzhang and Shi Yuanwang*
School of Public Health, Southeast University, 1School of Medicine and Holistic Integrative Medicine, Nanjing University of Chinese Medicine, 2Nanjing Drum Tower Hospital, Southeast University, Jiangsu, Nanjing 210009, People's Republic of China

Correspondence Address:
Shi Yuanwang, School of Public Health, Southeast University, Jiangsu, Nanjing 210009, People's Republic of China, E-mail: Stone_wang1986@163.com


To observe the clinical efficacy of Shuxuening injection in treating organophosphorus pesticide-induced myocarditis. In this study, we enrolled a total of 200 patients with organophosphorus pesticide-induced myocarditis, who were admitted to Nanjing Pukou District Traditional Chinese Medicine Hospital from September 2020 to April 2023. Random allocation resulted in the formation of two groups, namely the control group and the observation group, each consisting of 100 cases. Routine treatment was administered to the control group, involving procedures like gastric lavage, detoxification, safeguarding of vital organs (heart, liver, and kidneys), and anti-acetylcholine interventions. On the other hand, the observation group underwent routine treatment combined with the administration of Shuxuening injection. Following a 10 d period of continuous treatment, a comparison was made between the two groups regarding clinical symptoms, improvement of physical signs, electrocardiogram readings, and myocardial enzyme profiles. Comparing the clinical efficacy between the two groups, the observation group exhibited a total effective rate of 97.00 %, whereas the control group demonstrated a rate of 88.00 % (p<0.05), indicating a notable difference. After the completion of treatment, the number of patients in the observation group exhibiting ST-T segment changes in the electrocardiogram was 3, which was notably lower than the number in the control group (7 cases). The control group, on the other hand, had 11 and 16 cases, respectively (p<0.05). After completion of the treatment, there was a notable enhancement in all indicators of the myocardial enzyme profile, demonstrating superior results in the observation group compared to the control group (p<0.05). The administration of Shuxuening injection exhibits remarkable efficacy in the treatment of organophosphorus pesticide-induced myocarditis.

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