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Amycolatopsis sp. strain MN235945 Mediated Biosynthesis of Silver Nanoparticles: Characterization, Antimicrobial and Anticancer Activity against HeLa and MCF-7 Cell Lines

Author(s): Pallavi Sathyanarayana Swamy, M. P. Bhat and S. Nayaka*
Department of Botany, Karnatak University, Dharwad, Karnataka 580003, India

Correspondence Address:
S. Nayaka, Department of Botany, Karnatak University, Dharwad, Karnataka 580003, India, E-mail:

The current study investigated about the biogenic synthesis and evaluation of biological activities of Amycolatopsis sp. strain MN235945 fabricated silver nanoparticles and their characterization by ultraviolet-visible spectroscopy, fourier transform infrared spectroscopy, high resolution-transmission electron microscopy, energy dispersive X-ray spectroscopy, X-ray diffractometry and zeta potential analysis. The most potent isolate Amycolatopsis sp. strain MN235945 was identified by morphological and genotypic characterization and biological activity of silver nanoparticles was studied via antimicrobial and anticancer activity assays. The synthesized silver nanoparticles with spherical shape and polydispersed nature showed ultraviolet visible spectroscopy, absorption maximum at 417 nm with the smallest size of 19.40 nm. The presence of various biological functional groups and different elemental composition of silver nanoparticles were determined along with zeta potential value of -34.8 mV; whereas, the X-ray diffractometry analysis revealed the specific Bragg’s diffraction peaks for metallic silver. The silver nanoparticles with increased antimicrobial activity significantly inhibited cervical adenocarcinoma HeLa and human breast cancer MCF-7 tumour cells with IC50 values of 81.12 and 235.45 μg/ml respectively. These encouraging results obtained via low-cost green synthesis of silver nanoparticles from marine Amycolatopsis sp. strain MN235945 provide helpful information for further research and designing an anticancer agent in coming years using Amycolatopsis sp. strain MN235945 mediated silver nanoparticles with minimal side effects.

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