Abstract
Ornithogalum Saponin OSW-1 Negatively Regulates Dendritic Cells to Enhance Immune Function
Department of Oncology, 1Department of Respiratory Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, 2Department of Cancer Center, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning 116001, 3Development of Institute of Medicinal Plant, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730, China
Correspondence Address:
Feng Qi Fang, Department of Oncology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, China, E-mail: ffqlj@163.com
Liliaceae plant Ornithogalum caudatum Jacq. is applied in the treatment of inflammation and tumors in ancient Chinese medicine. However, the impact of OSW-1 on immune function is not yet fully understood. Therefore, seeking and exploring effective intervention measures for the immune escape of tumor cells is essential for the prevention and treatment of cancer recurrence and metastasis. The aim of this study was intended to observe the process of OSW-1 on the immune function status of regulatory dendritic cells, which opened up new ideas for studying the anti-tumor mechanism of OSW-1. Our experimental results has confirmed that Ornithogalum saponin OSW-1 has a clear inhibitory effect on the expression of regulatory dendritic cell surface receptor, toll-like receptor 4, blocking negative immune regulation of regulatory dendritic cells, promoting the proliferation of splenic lymphoid T cells and enhancing immune activity, indicating that OSW-1 can exert an anti-tumor mechanism by regulating immunosuppression. Our research provides a new theoretical basis for the anti-tumor mechanism of OSW-1.
Full-Text | PDF
