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Epigallocatechin Gallate Restrains Angiogenesis and Glycolysis in Colorectal Cancer via the Circular Ribonucleic Acid Actin Gamma 2/Micro Ribonucleic Acid-370-5p Pathway

Author(s): Chaolin Chen, Bixia Xuan, Wenchao Yang, Liuping Zhang, Jia Xu, Ling Xu and Ling Zheng*
Department of Pharmacy, 1Department of Hospital-Acquired Infection Control, 2Department of Cardiovascular Medicine, 3Organization Ministry of Personnel, Traditional Chinese Medical Hospital of Zhuji, 4Department of Pharmacy, Zhuji People’s Hospital, Zhuji, Zhejiang Province 311800, China

Correspondence Address:
Ling Zheng, Department of Pharmacy, Zhuji People’s Hospital, Zhuji, Zhejiang Province 311800, China, E-mail:

To figure out the pathway by which epigallocatechin gallate restrains angiogenesis and glycolysis in colorectal cancer through the circular ribonucleic acid (actin gamma 2)/microRNA-370-5p axis. Detection of circular actin gamma 2 and microRNA-370-5p in colorectal cancer patient tissues and cells and vascular endothelial growth factor A in colorectal cancer cells was conducted. Cell viability and proliferation, angiogenesis, glucose and lactate of colorectal cancer cells were examined. Circular actin gamma 2 and microRNA-370-5p's combination link was verified. Epigallocatechin gallate restrained cell viability, angiogenesis and glycolysis in colorectal cancer cells. In tissues and cells of colorectal cancer patients, circular actin gamma 2 was elevated but microRNA-370-5p was reduced. Elevation of circular actin gamma 2 or repression of microRNA-370-5p motivated vascular endothelial growth factor A, cell proliferation, angiogenesis and glycolysis in colorectal cancer cells. Meanwhile, it was demonstrated that circular actin gamma 2 competitively combined with microRNA-370-5p. MicroRNA-370-5p inhibitor turned around the repressive effect of epigallocatechin gallate and knockdown of circular actin gamma 2 on colorectal cancer progression. Circular actin gamma 2 competitively combines with microRNA-370-5p to control colorectal cancer progression and epigallocatechin gallate restrains colorectal cancer angiogenesis and glycolysis through the circular actin gamma 2/microRNA-370-5p pathway.

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