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Abstract

Estimation Of Rofecoxib By Difference Spectroscopy In Pharmaceutical Formulations

Author(s): S.J Rajput, M.G Sankalia

Difference spectrophotometric method was developed for the estimation of rofecoxib in bulk drug and in pharmaceutical formulations. Rofecoxib exists in two different forms in acidic and basic medium which differs in their UV spectra. Difference spectrum, obtained by keeping rofecoxib in 0.1 N NaOH in reference cell and rofecoxib in 0.1 N HNO3 in sample cell, showed two characteristics peaks at 219.2 nm and 260.8 nm with negative and positive absorbance respectively. Difference of absorbance between these two maxima was calculated to find out the amplitude, which was plotted against concentration. The method was found to be linear in the ranges of 2-16 μg/ml.

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