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Abstract

Ethyl Cellulose Microspheres Of Glipizide : Characterization, In Vitro And In Vivo Evaluation

Author(s): K. P. R Chowdary, N Koteswara Rao, K Malathi

Ethyl cellulose microspheres of glipizide were prepared by an industrially feasible emulsion-solvent evaporation technique and the microspheres were investigated. The microspheres are spherical, discrete and free-flowing. Encapsulation efficiency was in the range of 81-91%. Glipizide release from the microspheres was slow and diffusion controlled and extended over a period of 10 d and depended on core:coat ratio, wall thickness and size of the microspheres. Good linear relationships were observed between percent coat, wall thickness and release rate of the microspheres. In the in vivo, the microspheres produced a sustained hypoglycemic effect over 6 d in normal rabbits. These microspheres were found suitable for parenteral controlled release.

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