Abstract

Leaves of Solena amplexicaulis are traditionally used as a remedy for the treatment of inflammation related disorders in the form of decoction by the Paliyar tribal community of Theni district, Tamil Nadu, India. This study was designed to investigate the antiinflammatory and antioxidant potential of crude methanol leaf extract and the isolated compound, forskolin from S. amplexicaulis. Their effects were evaluated by carrageenan-induced paw edema in experimental rats for 4 h. In vivo antioxidant and histopathological studies were also performed. Therapeutic potential of forskolin was further substantiated using PASS software. The oral administration of forskolin (10 mg/kg) exerted potent antiinflammatory activity by reducing paw edema (87.79%) than the crude extract (150 and 300 mg/kg) and it was comparable with the standard drug, indomethacin (10 mg/kg, 93.89%). Consistent with these findings, antioxidant, histopathological architecture and PASS software also reflected its prominent curative property. The obtained results therefore suggest that the compound, forskolin obtained from S. amplexicaulis is considered to be a valuable source of remedy for inflammation.