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Evaluation Of Ascorbic Acid As An Inhibitor Of Lipid Peroxidation Induced By Cefotaxime Sodium And Metoprolol

Author(s): K Roy, S Rudra, A. U De, Chandana Sengupta

Ascorbic acid (AA) has been evaluated at three different concentrations equivalent to human doses of 100, 250 and 500 mg as an inhibitor of lipid peroxidation (LP) induced by two drugs, cefotaxime sodium (CS) and metoprolol (M) using goat whole blood as the lipid source and malonaldehyde (MA) content as the measure of LP. AA was found to significantly suppress in vitro lipid peroxidation caused by CS and M at all three dose levels. Paradoxically, AA per se increased MA content when used without drug. These findings are discussed in an attempt to explore possible potential of AA to reduce toxic effects of the drugs considering LP as a toxicity mediating process.


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