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Abstract

Evaluation of olibanum resin as microencapsulating agent for controlled drug delivery

Author(s): KPR Chowdary, P Mohapatra, MN Murali Krishna

Olibanum resin was evaluated as microencapsulating agent and to prepare resin-coated microcapsules. Resin-coated microcapsules of nifedipine were prepared by an industrially feasible emulsification-solvent evaporation method and the microcapsules were investigated. The resin-coated microcapsules are spherical, discrete, free-flowing and multinucleate monolithic type. Microencapsulation efficiency was in the range 98-105%. Nifedipine release from the resin-coated microcapsules was slow over 24 h and depended on core: coat ratio, wall thickness and size of the microcapsules. Drug release was by non-fickian diffusion mechanism. Good linear relationships were observed between wall thickness of the microcapsules and release rate and T50 values. Resin-coated microcapsules of nifedipine exhibited good controlled release characteristics and were found suitable for once a day oral controlled release products.

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