Evaluation of the Effects of Spinel Ferrite Nanoparticles on the Composition of Normal Human Blood Serum
Embryonic Stem Cell Research Unit, 1King Fahd Medical Research Center, 2Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, 3Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589 Saudi Arabia, 4Department of Biology, Abdelhamid bin Badis University, Mostaganem 27000, Algeria, 5Ibn Sina National College for Medical Studies, Jeddah 22421, 6Urology Department, King Abdulaziz Hospital, King Abdulaziz University, Jeddah 21589, Saudi Arabia
Mohammed Moulay, Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589 Saudi Arabia, E-mail: firstname.lastname@example.org
Magnetic ferrite-based nanoparticles have recently emerged as a promising alternative choice for the treatment of different types of cancer. Magnetic ferrite-based nanoparticles have already been used in diagnosis of various diseases and as a drug delivery vehicle. In this study, spinel ferrite nanoparticles were prepared using a hydrothermal approach which is a simple and cost-effective technique. Spinel ferrite nanoparticles were prepared from a variety of divalent metals including nickel, zinc, copper and cobalt. The impact of these nanoparticles on the composition of human blood serum was evaluated in vitro. Fourier-transform infrared and ultraviolet-visible absorption spectroscopies were used to examine the blood serum. According to the findings, all of the magnetic ferrite-based nanoparticles studies showed protein corona formation. The development of corona protein was due to the affinity of magnetic ferrite-based nanoparticles to interact with protein and size independent. The magnetic ferrite-based nanoparticles had no effect on the amino acid makeup of the serum. The magnetic ferrite-based nanoparticles exerted their efficacy by releasing a small amount of metal oxides into the serum. According to our findings, zinc ferrite was the most suited spinel ferrite nanoparticles to be evaluated further for their possible application in nanomedicine.