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Abstract

Exploring the Antidiabetic Potential of Ethanolic Extract of Boswellia ovalifoliolata Stem Bark Against Alloxan-Induced Diabetes in Wistar Rats

Author(s): Sugali Gayathri, Pappaka Radhika, M. Hemavathi, V. K. Nelson, S. S. Asrar, V. Mayasa, Sasikala Chinnappan, Onchonga Ondabu Rogers and S. R. Kanala*
Department of Pharmacology, Sri Krishnadevaraya University College of Pharmaceutical Sciences, Sri Krishnadevaraya University, Anantapur, Andhra Pradesh 515003, 1Raghavendra Institute of Pharmaceutical Education and Research, Chiyyedu, Andhra Pradesh 515721, 2GITAM School of Pharmacy, GITAM University, Hyderabad, Telangana 502329, India, 3Department of Pharmaceutical Sciences, University College Sedaya International (UCSI) University, Cheras, Kuala Lumpur 56000, Malaysia

Correspondence Address:
S. R. Kanala, Raghavendra Institute of Pharmaceutical Education and Research, Chiyyedu, Andhra Pradesh 515721, India, E-mail: somu.reddyvaru@gmail.com


The study aimed to identify the impact of oral supplementation of ethanolic extract of Boswellia ovalifoliolata in treating diabetes. Oral administration of ethanolic extract of Boswellia ovalifoliolata at doses of 200 mg/kg and 400 mg/kg was carried out for 21 d in rats that had been induced to diabetes by alloxan. To explore the effect of ethanolic extract of Boswellia ovalifoliolata on stress-induced pancreatic inflammation in alloxan-induced diabetic rats, the following parameters were assessed viz., blood glucose, hemoglobin A1c, insulin, lipid content, liver biochemical parameters, enzymatic and non-enzymatic antioxidants and inflammatory mediators. There was a marked improvement in blood glucose and hemoglobin A1c levels after 21 d of treatment as well as insulin and serum biochemical parameter restoration. This suggests that they may have the ability to boost endogenous insulin synthesis. Research on ethanolic extract of Boswellia ovalifoliolata's effects revealed that it possesses strong anti-inflammatory and antioxidant capabilities. The fact is that it could regulate the contents of malondialdehyde, protein carbonyl content, tumour necrosis factor-α and interleukin-6 in pancreatic tissue, as well as raise levels of superoxide dismutase, catalase and glutathione, proved this. In addition, ethanolic extract of Boswellia ovalifoliolata considerably reduced the cellular damage caused by alloxan to the islet and acinar cells of the pancreas. One possible explanation is that ethanolic extract of Boswellia ovalifoliolata contains boswellic acid. The results of this study provide promising evidence that ethanolic extract of Boswellia ovalifoliolata can improve diabetic indices, which could pave the way for a new approach to diabetes care. Finding new, all-natural ways to manage diabetes is a major goal of this study.

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