Abstract
Expression and Clinical Significance of Long Non-Coding Ribonucleic Acid LOC554202 and H19 in Serum of Cervical Cancer
Department of Gynecology and Obstetrics, The Maternal and Child Health Hospital of Hunan, Changsha, Hunan 410008, 1Department of Hematology and Oncology, The Fourth Hospital of Changsha, Changsha, Hunan 410013, 2Department of Emergency Medicine, Second Xiangya Hospital, Central South University, Changsha, Hunan 410006, China
Correspondence Address:
Yan Zhao, Department of Gynecology and Obstetrics, The Maternal and Child Health Hospital of Hunan, Changsha, Hunan 410008, China, E-mail: yansongzhi0674yab@163.com
To explore the serum expression of long non-coding ribonucleic acid H19 and LOC554202 in cervical cancer as well as the clinical significance is the main objective. Serum samples were collected from 52 preoperative cervical cancer patients, at the same time, the serum samples were also collected from 39 agematched women admitted due to gynecological benign diseases with cervical cancer screening negative were selected as the control group. Among them, 10 cervical cancer patients were used for preoperative and postoperative comparisons. The serum long non-coding ribonucleic acid H19 and LOC554202 levels in the above specimens were detected through real-time quantitative reverse transcription-polymerase chain reaction and the cervical cancer patients before and after surgery were compared. Meanwhile, the relationships of serum long non-coding ribonucleic acid H19 and LOC554202 levels in cervical cancer patients with their clinical pathological parameters were also analyzed and the receiver operating characteristic curve was adopted to evaluate the diagnostic efficiency of serum long non-coding ribonucleic acid H19 and LOC554202 levels. The serum long non-coding ribonucleic acid H19 and LOC554202 levels in cervical cancer patients were apparently elevated compared with those in control group, those after surgery were markedly declined relative to those before surgery, and the difference was of statistical significance (p<0.05). The serum long non-coding ribonucleic acid H19 and LOC554202 levels in cervical cancer patients were not correlated with age, pathological type, clinical classification (p<0.05). The area under the receiver operating characteristic curve, sensitivity and specificity of serum long non-coding ribonucleic acid H19 in independently diagnosing cervical cancer were 0.661, 30.8 % and 94.9 %, respectively, while those of serum long non-coding ribonucleic acid LOC554202 in independently diagnosing cervical cancer were 0.707, 69.2 % and 66.7 %, respectively. Serum long non-coding ribonucleic acid H19 and LOC554202 can serve as the potential circulatory markers for the clinical diagnosis and postoperative monitoring of cervical cancer.
