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Abstract

Expression and Clinical Significance of Tumor Markers CEA and CYFRA21-1 in Patients with Lung Cancer

Author(s): H. F. ZHANG, G. LI2, YONG XIA LIU3 AND YA JIE WANG4*
Department of Laboratory Medicine, Beijing xicheng District Ping’an Hospital, No. 169 Zhaodengyu Road, Beijing 100035, 1Department of Pathology, Beijing Tiantan Hospital, Capital Medical University, No 119 South 4 Round West Road, Beijing 100070, 2Department of Laboratory Medicine, Beijing xicheng Zhanlan Road Hospital, No. 16, Taoliuyuan West Alley, Beijing 100044, 3Department of Laboratory Medicine, Beijing Ditan Hospital, Capital Medical University, No. 8 Jingshun East Street, Beijing 100015, China

Correspondence Address:
YA JIE WANG, Department of Laboratory Medicine, Beijing Ditan Hospital, Capital Medical University, No. 8 Jingshun East Street, Beijing 100015, China, E-mail: [email protected]


To explore the application value of tumor markers carcinoembryonic antigen and cytokeratin 19 fragment in the progression and prognosis of middle-advanced non-small cell lung cancer. Clinical data of 97 patients initially diagnosed with lung lesions in our hospital from January 2018 to December 2019 were collected and divided into the lung cancer group and benign lesion group. There were 52 patients diagnosed with stage I or II lung cancer by computed tomography and clinical diagnosis in the lung cancer group and 45 patients with benign lesions in the benign lesion group. The levels of serum tumor markers were detected by electrochemiluminescence immunoassay. The results showed that the levels of carcinoembryonic antigen and cytokeratin 19 were significantly higher in the lung cancer group compared with the benign lesion group and the difference was statistically significant (p<0.05). Both carcinoembryonic antigen and cytokeratin 19 can be used in the diagnosis of squamous cell carcinoma and adenocarcinoma. The sensitivity of the combined detection was significantly higher than that of the single detection, while the specificity of the combined detection was significantly lower than that of carcinoembryonic antigen alone (p<0.05). In lung cancer with positive combined detection, the proportion of adenocarcinoma was significantly higher than that of squamous cell carcinoma. When cytokeratin 19 was positive and carcinoembryonic antigen was negative, the proportion of squamous cell carcinoma was significantly higher than that of adenocarcinoma. Serum carcinoembryonic antigen and cytokeratin 19 were abnormally highly expressed in non-Small cell lung cancer patients, which are useful for clinical diagnosing, treatment planning, efficacy monitoring, and prognosis evaluation.

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