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Abstract

Expression of Elicitin Response Protein plus Alpha-Chemokines in Lung Cancer

Author(s): Xiaoyan Li, Yuan Wang, Xiaoyue Chang*, L. Gao, Lina Peng, Hongxia Bai and H. J. Dong
Respiratory Department, Baotou Central Hospital, Baotou 014000, China

Correspondence Address:
Xiaoyue Chang, Respiratory Department, Baotou Central Hospital, Baotou 014000, China, E-mail: [email protected]


To investigate the expression of elicitin response protein and alpha-chemokines in lung cancer, inflammatory tissues and normal tissues and to observe the relationship between the expression of age, sex, tumor type, stage, differentiation and vascular endothelial growth factor. To detect the expression of chemokines in squamous cell carcinoma, adenocarcinoma and small cell lung cancer and analyze the relationship between the expression of age, gender, pathological grade and stage. The high expression rate of elicitin response protein and alpha-chemokines in lung cancer was higher than that in normal tissue and the difference was statistically significant (p<0.05). The expression of elicitin response protein and alpha-chemokines in different pathological types was different (p<0.001). The expression of elicitin response protein and alphachemokines in lung cancer was independent of age and gender. C-X-C motif chemokine ligand 3, C-X-C motif chemokine ligand 5 and C-X-C motif chemokine ligand 7, as elicitin response protein members, may play a more important role in lung cancer formation than other C-X-C motif chemokine ligand members. There was correlation between the expression of alpha-chemokine and vascular endothelial growth factor. Elicitin response protein and alpha-chemokines may play important role in development of lung cancer, especially the C-X-C motif chemokine ligand 3, C-X-C motif chemokine ligand 5 and C-X-C motif chemokine ligand 7 may become new potential diagnostic and therapeutic targets.

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