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Abstract

Extraction Of Solanum Trilobatum And The Effect Of Sobatum On Chromosomes

Author(s): P. V Mohanan, K Rathinam, K. S Devi

Petroleum ether, chloroform, ethyl acetate and ethanol were used for the extraction of Solanum trilobatum. The partially purified component of the plant named as sobatum was obtained from the petroleum ether:ethyl acetate (75:25) extractable portion. Apart from plant extraction, an effort was also made to evaluate the effect of sobatum on chromosomes. Groups of mice were administered sobatum (100, 200 and 400 mg/kg) or cyclophosphamide (100 mg/kg) followed by coichicine, which was administered 90 minutes before sacrificing the animals for arresting mitosis. It was shown that there was no variation in the chromosome number or significant abnormalities in the sobatum and DMSO treated groups, where as cyclophosphamide induced remarkable chromosomal abnormalities. This investigation revealed that the sobatum did not have the potential to induce any chromosomal aberrations in the bone marrow erthrocytes of swiss mice.

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Citations : 66710

Indian Journal of Pharmaceutical Sciences received 66710 citations as per google scholar report