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Extractive Spectrophotometric Determination Of Phenothiazine Drugs With Chlorophenol Red

Author(s): J Seetharamappa, B. K Shubha, P Nagaraja

A sensitive spectrophotometric method for the determination of chlorpromazine hydrochloride, promethazine hydrochloride, prochlorperazine maleate and trifluoperazine hydrochloride based on the formation of chloroform extractable complexes exhibiting maximum at 405 nm with chlorophenol red in acidic medium is described. A study of the effect of commonly associated excipients revealed that they did not interfere. Statistical analysis of the results indicates that the method is precise and accurate.


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