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Abstract

Extractive Spectrophotometric Estimation Of Fluoxetine Hydrochloride In Pharmaceutical Formulations

Author(s): M. T Naik, M. D Rokade, P. M Dhadke

A simple, fast and precise extractive spectrophotometric method for estimation of fluoxetine hydrochloride from pharmaceutical formulations has been proposed. It is based on extraction of colored complex formed between fluoxetine hydrochloride and bromothymol blue in chloroform. This yellow complex has an absorption maxima at 412 nm with molar extinction coefficient 13.6 X 103 1 mol-1 cm-1. The system obeys Beer’s law in the range of 1.5-20.0 mg/ml of fluoxetine hydrochloride. The proposed method gave reproducible results for determination of fluoxetine hydrochloride from pharmaceutical formulations.

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