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Flow of formulation granules through a conical hopper

Author(s): B Mazumder, R Rajan, Jasmina Khanam, A Nanda
Department of Pharmaceutical Technology, Jadavpur University, Kolkata-700 032, India

Correspondence Address:
B Mazumder Department of Pharmaceutical Technology, Jadavpur University, Kolkata-700 032 India E-mail: [email protected]

Gravity flow characteristics of various pharmaceutical granules through static conical hoppers of different cone angles were studied. Mass flow rate depends on properties of granules and cone angles when environmental conditions such as temperature and relative humidity are kept within a fixed range. The granules were made with active pharmaceutical ingredients as per Indian pharmacopoeia with other additives like binders and diluents. Lubricants were added with the granules to observe their effects on mass flow rate. Magnesium stearate and colloidal silicon dioxide of different proportions were used as lubricants after granulation. A new dimensionally analyzed equation was developed to predict flow rate of the granules. The developed equation agreed well with the experimental data with a percentage deviation of ±10%.

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