All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Formulation and Evaluation of Mesoporous Silica Nanoparticle Loaded Fast Dissolving Tablet of Tamoxifen

Author(s): V. V. JADHAV*
Quality Assurance Department, Appasaheb Birnale College of Pharmacy, Sangli, Maharashtra 416416, India

Correspondence Address:
V. V. JADHAV, Quality Assurance Department, Appasaheb Birnale College of Pharmacy, Sangli, Maharashtra 416416, India; E-mail: [email protected]


Breast cancer is a cancer which has significant societal impact because it generally affects the young age people. Tamoxifen is Biopharmaceutical Classification System class II drug. This active pharmaceutical ingredient have problem with solubility. Most of the anti-cancerous drugs have problem with solubility because of their complicated structures. To deal with this problem mesoporous silica nanoparticles of tamoxifen are prepared. Drug entrapped in mesoporous structure which is having size less than 200 nm. It leads to improvement in solubility and further bioavailability. Various studies after formulation show improvement in solubility and decrease in particle size. Further fast dissolving tablet is prepared to improve bioavailability. Pre compression studies and post compression studies show tablet dissolve within 30 s. Hence mesoporous silica nanoparticles are best way to improve solubility.

Full-Text | PDF