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Abstract

Formulation And Evaluation Of Nimodipine Tablets With Nimodipine Pregelatinized Starch

Author(s): K. P. R Chowdary, Rama N Rao

The objective of the present study is to formulate and evaluate nimodipine tablets employing nimodipine-pregelatinized starch dispersions. Dispersions of nimodipine (NM) in pregelatinized starch (PGS) were prepared in different drug and carrier ratios and were evaluated by XRD and DSC studies. NM tablets were formulated employing NM-PGS dispersions and their corresponding physical mixtures. The compressed tablets were evaluated for various tablet characteristics including dissolution rate and efficiency. Marked increase in the dissolution rate and efficiency was observed with tablets of dispersions In comparison to tablets formulated with NM-PGS physical mixtures. Dissolution of nimodipine from these tablets obeyed first-order kinetics.

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