All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Formulation And Evaluation Of Sustained Release Dosage Form Of Theophlline Using A Combined Hydrophobic And Hydrophilic Matrix

Author(s): B. S Nath, D Hiremath

Combination of aliphatic alcohol (cetyl alcohol)and partially hydrated methylcellulose was investigated as a sustained release matrix. Theophylline is used as a model drug for evaluating the matrix system. Cetyl alcohol and methyl cellulose were used in different proportions i.e., 2:1, 3:1, and 4:1 along with usual tablet additives, lactose and talc. The matrix component was varied from 20,25 and 30% w/w of total tablet weight. The in vitro release data showed that 30% w/w total matrix component gave extended release of theophylline for more than 8 h. Analysis of drug release rate from the matrix system indicated that the drug was released by anomalous diffusion obeying first order rate kinetics.

PDF

 
 
List of Supporting Conferences