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Formulation And Evaluation Of Topical Drug Delivery Systems Of Ciprofloxacin

Author(s): K. P. R Chowdary, P. A Kumar

Eight semisolid formulations belonging to anhydrous, cream (O/W and W/O), water soluble and gel categories were prepared and evaluated for drug release and antibacterial and antifungal activities. Ciprofloxacin release from mono-phasic systems (anhydrous, PEG base and gels) followed zero order kinetics and from biphasic systems (creams) followed Ötime release order. Overall, PEG and gel formulations gave higher release rate and exhibited higher antibacterial and antifungal activities when compared to cream and anhydrous bases.


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