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Formulation and in vitro evaluation of floating capsules of theophylline

Author(s): SB Bhise1, NH Aloorkar2
1Government College of Pharmacy, Karad-415 124, India 2Department of Pharmaceutics, Satara College of Pharmacy, Satara-415 004, India

Correspondence Address:
S B Bhise Government College of Pharmacy, Karad-415 124 India E-mail: [email protected]

Sustained release floating capsules for theophylline were fabricated using drug:polymer ratio of 30:70. The hydrocolloids were used in different proportions and four formulations were prepared. These formulations were optimized on the basis of buoyancy, matrix integrity, duration of floating and in vitro drug release. All the four formulations showed good buoyancy and matrix integrity. The duration of floating was more than 12 h for all formulations. In vitro drug release study of these formulations indicated controlled release of theophylline and about 76 percent drug was released at the end of 12 h.

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