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Formulation Development and In Vitro Evaluation of Diclofenac Sodium Injection for Pain Management

Author(s): A. Padiyar* and R. K. Maheshwari
Department of Pharmacy, Industrial Pharmacy Research Lab, Shri Govindram Seksaria Institute of Technology and Science, Indore, Madhya Pradesh 452003, 1School of Pharmacy and Technology Management, SVKM's NMIMS, Shirpur, Maharastra 425405, India

Correspondence Address:
A. Padiyar, School of Pharmacy and Technology Management, SVKM's NMIMS, Shirpur, Maharastra 425405, India, E-mail:

The current study aims to design, formulate, optimize and evaluate diclofenac sodium injection using a novel concept of solubilisation. The present formulation utilizes a mixed solvency concept for the development of an injectable dosage form of the sparingly water-soluble drug diclofenac sodium using solids as solubilizing compounds. Diclofenac sodium injection 75 mg/ml was formulated without using propylene glycol or any other liquid solubilize, hence can be injected through the intradeltoid route without any pain at the site of action. The developed formulation was evaluated for various parameters such as freeze-thaw study, viscosity, osmolality and physical, chemical and pH stability of formulations were studies. The outcomes of the study deciphered a successful formulation of diclofenac sodium injection using the mixed solvency concept.

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Citations : 66710

Indian Journal of Pharmaceutical Sciences received 66710 citations as per google scholar report