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Formulation Of Controlled Release Matrix Tablets Of Isosorbide Dinitrate

Author(s): I Haririan, A Ghaffari, M Mohammad-Pour

Different retardant polymers Including Carbopol 934P, HydroxyPropyl Methyl Cellulose (HPMC) (Methocel K4M) and Eudragit NE30D, RL30D and RS30D as release controlling materials were evaluated. The drug release medium consisted of hydrochloric acid buffer, pH-1.2, for the first two hours and phosphate buffer, pH-6.8, for the remaining period of time during the experiments. The influence of variables including polymer type, drug: polymer ratio, tablet filler type and tablet hardness on isosorbide dinitrate (ISDN) release profile was discussed. From the retardant polymers investigated, Eudragit NE30D exhibited proper release characteristics. The pattern of drug release from formulation prepared from Eudragit NE30D was shown to correspond to the Higuchi equation. According to the equation, Mt/, lSDN release mechanism from Eudragit NE30D matrix tablets (40 mg) was based on non-Fickian-Diffusion process. It was also realized that, matrix preparation was a suitable method for the formulation of ISDN-CR tablets.


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Citations : 53647

Indian Journal of Pharmaceutical Sciences received 53647 citations as per google scholar report