All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Formulation Optimization of Topical Simvastatin Emulgel by Box Behnken Method

Author(s): Surbhi Gupta and A. Anand*
Department of Pharmaceutics, Hygia Institute of Pharmaceutical Education and Research, Prabandh Nagar, Lucknow, Uttar Pradesh 226020, India

Correspondence Address:
A. Anand, Department of Pharmaceutics, Hygia Institute of Pharmaceutical Education and Research, Prabandh Nagar, Lucknow, Uttar Pradesh 226020, India, E-mail: anubhavanand2000@gmail.com


Simvastatin is classified as a biopharmaceutics classification system class II drug. Emulgel is a superior alternative for biopharmaceutics classification system class II drugs with low solubility and high permeability. For emulgel preparation, the solubility of simvastatin was assessed in sesame, groundnut and olive oil. The maximum solubility of simvastatin is found in sesame oil (21.06 mg/ml). Simvastatin emulgel was prepared and optimized using a three-factor, three-level Box-Behnken design. For optimization, concentrations of carbopol 934, sesame oil and surfactant (Tween 80) were selected as independent variable and viscosity, spreadability and in vitro drug release was selected as dependent variables, which are critical components of any semisolid formulation, as well as patient compliance. The optimized formulation was evaluated for viscosity, spreadability, pH, drug content and ex vivo release. The optimized formulation had 6875±531.21 mPas of viscosity, spreadability of 10.1446±0.31 gcm/s and in vitro drug release of 40.75±0.42 %, respectively. Ex vivo release investigations revealed that 42.15±0.32 % of simvastatin was released in 24 h. The study results demonstrated that the simvastatin emulgel might be an alternative the conventional topical administration form.

Full-Text | PDF

 
 
Google scholar citation report
Citations : 69022

Indian Journal of Pharmaceutical Sciences received 69022 citations as per google scholar report