All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.


Four Simple Spectrophotometric Determinations Of Lisinopril In Pure State And In Tablets

Author(s): P Aruna Devi, G.P.V Mallikarjuna Rao, K.M.M Krishna Prasad, C.S.P Sastry

Four simple and sensitive procedures (methods A, B, C and D) for the assay of lisinopril in pure form and formulations are described. Methods A and B are based on the condensation of lisinopril (acyclic imino acid) with ninhydrin (indane-1,2,3-trione hydrate) in the presence of ascorbic acid (method A, λmax 560 nm) or ascorbic acid (method B, λmax 520 nm). Method C is based on the initial , formation of water insoluble adduct involving lisinopril and phosphomolybdic acid, followed by release of phosphomolybdic acid from the adduct with acetone and color development with cobalt nitrate-ethylenediaminetetraacetic acid disodium salt complex (λmax 840 nm). Method D is based on the formation of colored radical anion on treating lisinopril with 2,3-dichloro,5,6-dicyanol, 4-benzoquinone (λmax 4 60 nm). The variable parameters in all these methods have been optimized. The results were statistically validated.


Google scholar citation report
Citations : 53647

Indian Journal of Pharmaceutical Sciences received 53647 citations as per google scholar report