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Fourth Derivative Spectrophotometric Estimation Of Ciprofloxacinamide And N,N'-bis Hydroxymethylciprofloxacinamide In Presence Of Ciprofloxacin

Author(s): B. B Nayak, M. S Bhatia, D. K Jain, P Trivedi

A simple fourth derivative spectrophotometric method for determination of ciprofloxacinamide and N,N’-bishydroxymethyl ciprofloxacinamide in presence of ciprofloxacin is presented. The procedure consists of measuring the amplitudes of the fourth derivative spectra of ciprofloxacinamide and ciprofloxacin at 286 nm and 277.4 nm respectively and that of N,N’-bishydroxymethyl cirpofloxacinamide and ciprofloxacin at 286 nm and 276.9 nm, respectively. Zero crossing technique is used for these estimations.


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