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Free radical scavenging activity of leaves of Alocasia indica (Linn)

Author(s): WA Mulla1, VR Salunkhe1, SB Kuchekar2, MN Qureshi3
1 Government College of Pharmacy, Vidyanagar, Karad-415 124, India 2 AISSMS College of Pharmacy, Pune-415 005, India 3 AIT Institute of Pharmacy, Malegaon-423 203, Nasik, India

Correspondence Address:
W A Mulla Government College of Pharmacy, Vidyanagar, Karad-415 124 India [email protected]

The free radical scavenging potential of the plant Alocasia indica (Linn.) was studied by using different antioxidant models of screening like scavenging of 1,1-diphenyl-2-picryl hydrazyl radical, nitric oxide radical, superoxide anion radical, hydroxyl radical, iron chelating activity, total antioxidant capacity, non-enzymatic glycosylation of haemoglobin, rapid screening for antioxidant compounds by thin layer chromatography. The hydroalcoholic extract at 1000 Î?g/ml showed maximum scavenging of superoxide radical (87.17) by riboflavin-NBT-system, followed by scavenging of stable radical 1,1-diphenyl-2-picryl hydrazyl radical (83.48%), nitric oxide radical (74.09%) hydroxyl radical (60.96%) at the same concentration. However the extract showed only moderate activity by iron chelation (68.26%). That could be due to higher phenolic content in the extract. This finding suggests that hydro alcoholic extract of A. indica possess potent in vitro antioxidant activity as compared to the standard ascorbic acid. The results justify the therapeutic applications of the plant in the indigenous system of medicine, augmenting its therapeutic value.

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